Severe infection – Communicable Diseases Research

SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses in Human Colon Epithelial Cells

Article

Published on 2022-10-262022-11-15
Journal: Microbiology Spectrum
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제,

Factors Associated With Severe COVID-19 Among Vaccinated Adults Treated in US Veterans Affairs Hospitals

Article

Published on 2022-10-032022-11-15
Journal: JAMA Network Open
[Category] COVID19(2023년), SARS, 치료제,

[키워드] 95% CI adjusted odds ratio Affair age antiviral therapy association benefit black blood oxygen level booster booster vaccination Breakthrough infection Characteristics Chemotherapy chronic condition Chronic kidney disease collected Comorbidities conditions COVID-19 death defined Dementia demographic Department development Dexamethasone diagnostic disease dose effort end-organ Factor finding heart failure Hispanic Hospitalization hospitals identify immunocompromised status Immunosuppressive medication increase in increased risk Infection laboratory-confirmed SARS-CoV-2 infection less leukemia leukocyte logistic regression models lymphoma male mechanical ventilation men Older outcome Patient positive preexposure prophylaxis proportion receipt reduced retrospective cohort retrospective cohort study risk risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination severe COVID-19 severe COVID-19 disease severe disease Severe infection supplemental oxygen treated vaccination Vaccine variables veteran veterans white
[DOI] 10.1001/jamanetworkopen.2022.40037 PMC 바로가기

Comparing the expression levels of tripartite motif containing 28 in mild and severe COVID-19 infection

Article

Published on 2022-10-032022-11-15
Journal: Virology Journal
[Category] 치료제,

[키워드] 25-hydroxyvitamin D age Analysis antiviral immune response association cholesterol control group coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 patients determine differential expression disease downregulation enrolled Epigenetic erythrocyte sedimentation rate ESR evaluated expression level HDL healthy control high-density in both group indicated Infection LDL low-density Mild mild infection motif mRNA level multivariate logistic regression Patient patients PCR cycle polymerase chain Proteins qPCR reduction in required Severe COVID-19 Infection severe group Severe infection severe infections severity severity of COVID-19 significantly lower the mean threshold TRIM28 Tripartite Motif Tripartite motif containing 28. was used
[DOI] 10.1186/s12985-022-01885-0 PMC 바로가기

The Pitfalls of Mining for QuantiFERON Gold in Severely Ill Patients With COVID-19

Research article

Published on 2022-10-012022-10-05
Journal: Mayo Clinic Proceedings: Innovations, Quality & Outcomes
[Category] 치료기술,

[키워드] Additive Analysis assessment C-reactive protein Cohort Coronavirus disease 2019 COVID-19 COVID-19 admission COVID-19 cohort COVID-19 infection COVID-19coronavirus disease 2019 CRPC-reactive protein demonstrated elevated evaluate Factor ferritin Follow-up GBMgradient boosting machine generate gold gradient boosting machine IGRAinterferon-gamma release assay Ill indeterminate Inflammatory marker Interferon-gamma interferon-gamma release assay interleukin-6 lactate dehydrogenase latent tuberculosis infection LDHlactate dehydrogenase leukocyte likelihood LTBIlatent tuberculosis infection lymphocyte management Mayo Clinic objective Patient patient population patients hospitalized patients without COVID-19 Platelet Pneumonia proportion QFT-PlusQuantiFERON-TB Gold Plus QuantiFERON QuantiFERON-TB Gold Plus Result risk screening test severe coronavirus disease severe COVID-19 Severe COVID-19 Infection Severe infection SHapley Additive exPlanations SHAPSHapley Additive exPlanations was performed
[DOI] 10.1016/j.mayocpiqo.2022.06.004 [Article Type] Research article

Multiple Post-SARS-COV2 Infectious Complications in Kidney Transplant Recipient

Article

Published on 2022-09-292022-11-15
Journal: Medicina
[Category] SARS, 진단,

Persistent but dysfunctional mucosal SARS-CoV-2-specific IgA and low lung IL-1β associate with COVID-19 fatal outcome: A cross-sectional analysis

Article

Published on 2022-09-292022-11-15
Journal: Frontiers in Immunology
[Category] SARS, 변종, 진단, 치료기술,

[키워드] acute respiratory syndrome addition Antibody Response Antigen BAL Bronchoalveolar lavage clearance coronavirus coronavirus disease COVID-19 cross-sectional analysis domain fatal COVID-19 function IgA IgG IL-1β immune complex Infection Inflammatory Inflammatory cytokine lung mucosal mucosal immunity neutralization Neutralizing activity Neutralizing titer nucleocapsid protein outcome Patient persistent Protective RBD RBD variants reduced replicate SARS-CoV-2 SARS-CoV-2-specific antibody severe COVID-19 patients Severe infection severe infection. Survivors tested viral clearance virus virus virus elimination with COVID-19 Wuhan
[DOI] 10.3389/fimmu.2022.842468 PMC 바로가기

COVID-19 in unvaccinated patients with inborn errors of immunity-polish experience

Article

Published on 2022-09-232022-11-15
Journal: Frontiers in Immunology
[Category] SARS, 치료제,

[키워드] accounted Adult patient Adults analysis anti-SARS-CoV-2 Antibiotic therapy antibody-based therapy Antiviral children Comorbidity Complication coronavirus 2 Course COVID-19 COVID-19 symptoms COVID-19 unvaccinated patients death rate deficiency demonstrated diagnosed group high risk humoral immune Immunity immunodeficiency inborn errors of immunity. Inflammatory occurred pandemic Patient patients pediatric Prophylaxis reported required respiratory Retrospective study SARS-CoV-2 Severe infection significantly more study group symptomatic syndrome systemic the disease the study group therapy vaccination was used X-linked agammaglobulinemia
[DOI] 10.3389/fimmu.2022.953700 PMC 바로가기

Autoantibodies elicited with SARS-CoV-2 infection are linked to alterations in double negative B cells

Article

Published on 2022-09-052022-11-15
Journal: Frontiers in Immunology
[Category] SARS, 진단,

[키워드] Activation alteration antibodies autoantibodies autoantibody Autoimmune disease autoreactive autoreactive antibody B cell B cells BCR Cell changes in characterized CRP described DN1 DN2 DN3 DN3 cells DN4 double negative elevated elicited Frequency functional heterogenous IFNγ IL-1β IL-6 Immunoglobulin increase increase in Infection Inflammation Inflammation. interferon negative precursor pro-inflammatory cytokine reduction in reported SARS-COV-2 infection SARS–CoV–2 secreting cell serum Severe infection severe SARS-CoV-2 Signaling significantly subset systemic inflammation systemic level TNFα viral infection
[DOI] 10.3389/fimmu.2022.988125 PMC 바로가기

COVID-19 infection after two doses of SARS-CoV-2 mRNA vaccine in multiple sclerosis, AQP4-antibody NMOSD and MOGAD

Observational Study

Published on 2022-09-012022-10-05
Journal: Multiple sclerosis and related disorders
[Category] COVID19(2023년), SARS, 임상, 진단,

[키워드] Analysis anti-CD20 calculated conducted COVID-19 COVID-19 infection demographics disease disorder dose Follow-up Future help highest increased risk infected patients infected with COVID-19 Infection infection rate infection risk interferons investigated majority Mild MOGAD mRNA vaccination mRNA vaccine Multiple multiple sclerosis Neuromyelitis Neuromyelitis Optica observation oxygen supplementation Patient patients Prednisolone Prevent prospective observational study recruited required risk of COVID-19 robust SARS-CoV-2 Severe infection Singapore subsequent symptomatic therapy vaccinated individual vaccination Vaccinations vaccine. was collected were recorded
[DOI] 10.1016/j.msard.2022.104003 PMC 바로가기 [Article Type] Observational Study

Pathogen Profile of Children Hospitalised with Severe Acute Respiratory Infections during COVID-19 Pandemic in the Free State Province, South Africa

남아프리카 공화국 프리 스테이트 주에서 COVID-19 팬데믹 기간 동안 중증 급성 호흡기 감염으로 입원한 어린이의 병원체 프로필

Article

Published on 2022-08-212022-09-11
Journal: International Journal of Environmental Research an
[Category] SARS, 치료기술, 치료제,

[키워드] absence Acute respiratory infection acute respiratory infections acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aetiology change children circulation Co-infection collected complicate contribute coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 transmission Ct values detection rate Diagnosis exacerbated Free Immunity infection control Influenza Influenza virus measure Mortality negativity Panel pathogen Pathogens profile QIAstat-Dx® Respiratory SARS-CoV-2 Panel respiratory respiratory infections respiratory pathogen Respiratory pathogens respiratory syncytial virus respiratory virus respiratory viruses SARI SARS-CoV-2 severe acute respiratory infections severe acute respiratory syndrome Coronavirus Severe infection severe infections South Africa state susceptibility Swab Treatment Viral detection virus waned Waves waves of COVID-19 pandemic.
[DOI] 10.3390/ijerph191610418 PMC 바로가기 [Article Type] Article